COPS8 Antikörper (AA 150-198)

Produktnummer ABIN7148507

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch COPS8 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für COPS8 Antikörper (AA 150-198) (ABIN7148507)

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS8 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-COPS8 Antikörper

Bindungsspezifität: AA 150-198

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu COPS8

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Andere Bezeichnung: COPS8

Hintergrund:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: COP9 homolog antibody, COP9 signalosome complex subunit 8 antibody, COP9 signalosome subunit 8 antibody, Cops8 antibody, CSN8 antibody, CSN8_HUMAN antibody, hCOP9 antibody, JAB1 containing signalosome subunit 8 antibody, JAB1-containing signalosome subunit 8 antibody, SGN8 antibody, Signalosome subunit 8 antibody

UniProt: Q99627

Pathways: Zellzyklus