C4B Antikörper (AA 1454-1744)

Produktnummer ABIN7148365

Dieses Anti-C4B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von C4B in IHC und ELISA. Geeignet für Human.

Kurzübersicht für C4B Antikörper (AA 1454-1744) (ABIN7148365)

Target: C4B (C4b) (Complement Component C4b (C4b))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C4B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-C4B Antikörper

Bindungsspezifität: AA 1454-1744

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Complement C4-B protein (1454-1744AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu C4B

Target: C4B (C4b) (Complement Component C4b (C4b))

Andere Bezeichnung: C4B

Hintergrund:

Background: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Ref.16 Ref.17 Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Aliases: Basic complement C4 antibody, C2B5 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody, C4b antibody, C4B1 antibody, C4B2 antibody, C4B3 antibody, CO4B_HUMAN antibody, Complement C4 gamma chain antibody, Complement component 4B antibody, CPAMD3 antibody

UniProt: P0C0L5

Pathways: Komplementsystem