CHMP4B Antikörper (AA 1-224)

Produktnummer ABIN7147524

Der Kaninchen Polyklonal Anti-CHMP4B-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, CHMP4B in Proben von Human zu detektieren.

Kurzübersicht für CHMP4B Antikörper (AA 1-224) (ABIN7147524)

Target: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHMP4B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-CHMP4B Antikörper

Bindungsspezifität: AA 1-224

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Charged multivesicular body protein 4b protein (1-224AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CHMP4B

Target: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Andere Bezeichnung: CHMP4B

Hintergrund:

Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: Charged multivesicular body protein 4b antibody, CHM4B_HUMAN antibody, chmp4b antibody, Chromatin-modifying protein 4b antibody, hSnf7-2 antibody, hVps32-2 antibody, SNF7 homolog associated with Alix 1 antibody, SNF7-2 antibody, Vacuolar protein sorting-associated protein 32-2 antibody, Vps32-2 antibody

UniProt: Q9H444