RAD1 Antikörper (AA 1-282)

Produktnummer ABIN7147263

Der Kaninchen Polyklonal Anti-RAD1-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, RAD1 in Proben von Human zu detektieren.

Kurzübersicht für RAD1 Antikörper (AA 1-282) (ABIN7147263)

Target: RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RAD1 Antikörper

Bindungsspezifität: AA 1-282

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Cell cycle checkpoint protein RAD1 protein (1-282AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RAD1

Target: RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))

Andere Bezeichnung: RAD1

Hintergrund:

Background: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\\\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3\\\'->5\\\' double stranded DNA exonuclease activity.

Aliases: Cell cycle checkpoint protein Hrad1 antibody, Cell cycle checkpoint protein Rad 1 A / B antibody, Cell cycle checkpoint protein RAD1 antibody, Checkpoint control protein HRAD1 antibody, Checkpoint control protein RAD1 antibody, DNA repair exonuclease antibody, DNA repair exonuclease rad1 antibody, DNA repair exonuclease rad1 homolog antibody, DNA repair exonuclease REC1 antibody, DNA repair protein RAD1 antibody, EC 3.1.11.2 antibody, Exonuclease homolog RAD1 antibody, GTP-binding protein RAD antibody, hRAD 1 antibody, hRAD1 antibody, MGC77779 antibody, RAD 1 antibody, RAD antibody, RAD1 antibody, RAD1 homolog (S. pombe) antibody, RAD1 homolog antibody, Rad1 like DNA damage checkpoint antibody, Rad1 like DNA damage checkpoint protein antibody, RAD1, S. pombe, homolog of antibody, Rad1-like DNA damage checkpoint protein antibody, RAD1_HUMAN antibody, Ras associated with diabetes antibody, REC 1 antibody, REC1 antibody, RRAD antibody

UniProt: O60671

Pathways: M Phase