CAMK2B Antikörper (AA 1-300)

Produktnummer ABIN7146447

Der Kaninchen Polyklonal Anti-CAMK2B-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, CAMK2B in Proben von Human zu detektieren.

Kurzübersicht für CAMK2B Antikörper (AA 1-300) (ABIN7146447)

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAMK2B Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CAMK2B Antikörper

Bindungsspezifität: AA 1-300

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Calcium/calmodulin-dependent protein kinase type II subunit beta protein (1-300AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CAMK2B

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Andere Bezeichnung: CAMK2B

Hintergrund:

Background: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Aliases: Calcium/calmodulin dependent protein kinase (CaM kinase) II beta antibody, Calcium/calmodulin dependent protein kinase II beta antibody, Calcium/calmodulin dependent protein kinase IIB antibody, Calcium/calmodulin dependent protein kinase type II beta chain antibody, calcium/calmodulin-dependent protein kinase II beta antibody, Calcium/calmodulin-dependent protein kinase type II subunit beta antibody, CAM 2 antibody, CaM kinase II beta chain antibody, CaM kinase II beta subunit antibody, CaM kinase II subunit beta antibody, CaM-kinase II beta chain antibody, CAM2 antibody, CAMK 2 antibody, CAMK 2B antibody, CaMK II beta subunit antibody, CaMK II subunit beta antibody, CaMK-II subunit beta antibody, CAMK2 antibody, CaMK2 beta antibody, Camk2b antibody, CAMKB antibody, CaMKII beta subunit antibody, CaMKIIB antibody, KCC2B_HUMAN antibody, MGC29528 antibody, Proline rich calmodulin dependent protein kinase antibody, proline rich calmodulin-dependent protein kinase antibody

UniProt: Q13554

Pathways: WNT Signalweg, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity