MICU1 Antikörper (AA 55-191)

Produktnummer ABIN7146322

Dieses Anti-MICU1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MICU1 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für MICU1 Antikörper (AA 55-191) (ABIN7146322)

Target: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MICU1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MICU1 Antikörper

Bindungsspezifität: AA 55-191

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MICU1

Target: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Andere Bezeichnung: MICU1

Hintergrund:

Background: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Aliases: Allergen Hom s 4 antibody, ara CALC antibody, atopy related autoantigen antibody, atopy related autoantigen CALC antibody, Atopy-related autoantigen CALC antibody, CALC antibody, calcium binding atopy related autoantigen 1 antibody, Calcium uptake protein 1 antibody, calcium uptake protein 1, mitochondrial antibody, Calcium-binding atopy-related autoantigen 1 antibody, CBARA1 antibody, EFHA3 antibody, FLJ12684 antibody, MICU1 antibody, MICU1_HUMAN antibody, mitochondrial antibody, mitochondrial calcium uptake 1 antibody, MPXPS antibody

UniProt: Q9BPX6