BOK Antikörper (AA 15-103) (FITC)

Produktnummer ABIN7145316

Der Kaninchen Polyklonal Anti-BOK-Antikörper wurde für validiert. Er ist geeignet, BOK in Proben von Human zu detektieren.

Kurzübersicht für BOK Antikörper (AA 15-103) (FITC) (ABIN7145316)

Target: BOK (BCL2-Related Ovarian Killer (BOK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BOK Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-BOK Antikörper (FITC)

Bindungsspezifität: AA 15-103

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Bcl-2-related ovarian killer protein (15-103AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BOK

Target: BOK (BCL2-Related Ovarian Killer (BOK))

Andere Bezeichnung: BOK

Hintergrund:

Background: Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apototic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).

Aliases: Bcl 2 related ovarian killer protein antibody, Bcl-2-like protein 9 antibody, Bcl-2-related ovarian killer protein antibody, BCL2 related ovarian killer antibody, Bcl2-L-9 antibody, BCL2L9 antibody, BOK antibody, BOK_HUMAN antibody, BOKL antibody, Hbok antibody, MGC4631 antibody

UniProt: Q9UMX3

Pathways: Positive Regulation of Endopeptidase Activity