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BOK Antikörper (N-Term)

BOK Reaktivität: Human, Maus, Ratte ELISA, WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257961
  • Target Alle BOK Antikörper anzeigen
    BOK (BCL2-Related Ovarian Killer (BOK))
    Bindungsspezifität
    • 14
    • 11
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 44
    • 11
    • 5
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 42
    • 2
    Kaninchen
    Klonalität
    • 44
    Polyklonal
    Konjugat
    • 19
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BOK Antikörper ist unkonjugiert
    Applikation
    • 27
    • 27
    • 13
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    BOK Antibody detects endogenous levels of total BOK.
    Homologie
    Pig,Bovine,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human BOK, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product BOK Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    BOK (BCL2-Related Ovarian Killer (BOK))
    Andere Bezeichnung
    BOK (BOK Produkte)
    Synonyme
    BOK antikoerper, bok antikoerper, zgc:100979 antikoerper, zgc:64041 antikoerper, BCL2L9 antikoerper, BOKL antikoerper, Bok-BH3 antikoerper, AI847676 antikoerper, AU021146 antikoerper, matador antikoerper, mtd antikoerper, BOK, BCL2 family apoptosis regulator antikoerper, BCL2-related ovarian killer a antikoerper, BCL2-related ovarian killer b antikoerper, BCL2-related ovarian killer antikoerper, BOK antikoerper, boka antikoerper, bokb antikoerper, Bok antikoerper
    Hintergrund

    Description: Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).

    Gene: BOK

    Molekulargewicht
    23 kDa
    Gen-ID
    666
    UniProt
    Q9UMX3
    Pathways
    Positive Regulation of Endopeptidase Activity
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