OAS3 Antikörper (AA 424-565)

Produktnummer ABIN7142174

Produktdetails anti-OAS3 Antikörper

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Bindungsspezifität: AA 424-565

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OAS3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human 2\'-5\'-oligoadenylate synthase 3 protein (424-565AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu OAS3

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Andere Bezeichnung: OAS3 (OAS3 Produkte)

Synonyme: p100 antikoerper, Oasl10 antikoerper, 2'-5'-oligoadenylate synthetase 3 antikoerper, 2'-5' oligoadenylate synthetase 3 antikoerper, OAS3 antikoerper, Oas3 antikoerper

Hintergrund:

Background: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2\'-5\'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

Aliases: (2-5'')oligo(A) synthase 3 antibody, 2 5' oligo(A) synthetase 3 antibody, 2 5'LIGO antibody, 2 5A synthetase 3 antibody, 2''-5''-oligoadenylate synthase 3 antibody, 2-5A synthase 3 antibody, MGC133260 antibody, OAS3 2' 5' oligoadenylate synthetase 3, 100 kDa antibody, OAS3 antibody, OAS3_HUMAN antibody, p100 antibody, p100 OAS antibody, p100OAS antibody

UniProt: Q9Y6K5

Pathways: Hepatitis C