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OAS3 Antikörper (C-Term)

OAS3 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB1945 unconjugated
Produktnummer ABIN390166
  • Target Alle OAS3 Antikörper anzeigen
    OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))
    Bindungsspezifität
    • 15
    • 7
    • 7
    • 5
    • 1
    • 1
    • 1
    AA 1056-1087, C-Term
    Reaktivität
    • 39
    • 16
    • 2
    Human
    Wirt
    • 38
    • 1
    Kaninchen
    Klonalität
    • 39
    Polyklonal
    Konjugat
    • 11
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser OAS3 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 21
    • 13
    • 13
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This OAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1087 amino acids from the C-terminal region of human OAS3.
    Klon
    RB1945
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product OAS3 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Ibsen, Gad, Thavachelvam, Boesen, Desprès, Hartmann: "The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation." in: Journal of virology, Vol. 88, Issue 24, pp. 14222-31, (2014) (PubMed).

  • Target
    OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))
    Andere Bezeichnung
    OAS3 (OAS3 Produkte)
    Synonyme
    p100 antikoerper, Oasl10 antikoerper, 2'-5'-oligoadenylate synthetase 3 antikoerper, 2'-5' oligoadenylate synthetase 3 antikoerper, OAS3 antikoerper, Oas3 antikoerper
    Hintergrund
    OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.
    Molekulargewicht
    121170
    Gen-ID
    4940
    NCBI Accession
    NP_006178
    UniProt
    Q9Y6K5
    Pathways
    Hepatitis C
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