LC3B Antikörper (AA 1-116)

Produktnummer ABIN7140912

Der Kaninchen Polyklonal Anti-LC3B-Antikörper wurde für ELISA validiert. Er ist geeignet, LC3B in Proben von Candida sp. zu detektieren.

Kurzübersicht für LC3B Antikörper (AA 1-116) (ABIN7140912)

Target: LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))

Reaktivität: Candida sp.

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LC3B Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-LC3B Antikörper

Bindungsspezifität: AA 1-116

Kreuzreaktivität: Candida sp.

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Candida glabrata Autophagy-related protein 8 protein (1-116AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LC3B

Target: LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))

Andere Bezeichnung: ATG8

Hintergrund:

Background: Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.

Aliases: ATG8 antibody, AUT7 antibody, CAGL0A04675gAutophagy-related protein 8 antibody, Autophagy-related ubiquitin-like modifier ATG8 antibody

UniProt: Q6FXR8

Pathways: Autophagie