PEN2 Antikörper (AA 39-57) (Biotin)

Produktnummer ABIN7139852

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PEN2 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PEN2 Antikörper (AA 39-57) (Biotin) (ABIN7139852)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PEN2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-PEN2 Antikörper (Biotin)

Bindungsspezifität: AA 39-57

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Peptide sequence from Human Gamma-secretase subunit PEN-2 protein (39-57AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Andere Bezeichnung: PSENEN

Hintergrund:

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).

Aliases: Gamma secretase subunit PEN 2 antibody, Gamma Secretase Subunit PEN2 antibody, Gamma-secretase subunit PEN-2 antibody, Hematopoietic stem/progenitor cells protein MDS033 antibody, MDS033 antibody, MSTP064 antibody, PEN 2 antibody, PEN2_HUMAN antibody, Presenilin Enhancer 2 antibody, Presenilin enhancer 2 homolog antibody, Presenilin enhancer protein 2 antibody, PSEN2 antibody, psenen antibody

UniProt: Q9NZ42

Pathways: Notch Signalweg, Neurotrophin Signalübertragung