PEN2 Antikörper (C-Term)

Produktnummer ABIN2788066

Produktdetails anti-PEN2 Antikörper

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Meerschweinchen, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PEN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PSENEN. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSENEN

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 101 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Andere Bezeichnung: PSENEN (PSENEN Produkte)

Synonyme: MSTP064 antikoerper, PEN-2 antikoerper, PEN2 antikoerper, Psenen antikoerper, ACYPI006208 antikoerper, 1700023M09Rik antikoerper, Pen-2 antikoerper, RGD1312037 antikoerper, CG33198 antikoerper, Dmel\\CG33198 antikoerper, anon-AE003800.1 antikoerper, dPen-2 antikoerper, psenen antikoerper, pen-2 antikoerper, pen2 antikoerper, zgc:109727 antikoerper, presenilin enhancer gamma-secretase subunit antikoerper, presenilin enhancer 2 antikoerper, presenilin enhancer gamma secretase subunit antikoerper, Gamma-secretase subunit pen-2 antikoerper, presenilin enhancer antikoerper, presenilin enhancer gamma secretase subunit S homeolog antikoerper, PSENEN antikoerper, PEN2 antikoerper, Psenen antikoerper, pen-2 antikoerper, psenen.S antikoerper, psenen antikoerper

Hintergrund: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Alias Symbols: MDS033, MSTP064, PEN-2, PEN2
Protein Interaction Partner: APH1A, ERLIN2, THBD, APH1B, PSEN2, PSEN1, TMED10, NCSTN,
Protein Size: 101

Molekulargewicht: 12 kDa

Gen-ID: 55851

NCBI Accession: NM_172341, NP_758844

UniProt: Q9NZ42

Pathways: Notch Signalweg, Neurotrophin Signalübertragung