BUB3 Antikörper (pTyr207)

Produktnummer ABIN7138956

Der Kaninchen Polyklonal Anti-BUB3-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, BUB3 in Proben von Human zu detektieren.

Kurzübersicht für BUB3 Antikörper (pTyr207) (ABIN7138956)

Target: BUB3 (Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast) (BUB3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BUB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-BUB3 Antikörper

Bindungsspezifität: pTyr207

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Tyrosine 207 (V-E-Y(p)-L-D) derived from Human Bub3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BUB3

Target: BUB3 (Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast) (BUB3))

Andere Bezeichnung: BUB3

Hintergrund:

Background:

Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

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Seeley T.W., Wang L., Zhen J.Y.Biochem. Biophys. Res. Commun. 257:589-595(1999)

Tang Z., Shu H., Oncel D., Chen S., Yu H.Mol. Cell 16:387-397(2004)

Logarinho E., Resende T., Torres C., Bousbaa H.Mol. Biol. Cell 19:1798-1813(2008)

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Aliases: Aa2-050 antibody, AU019800 antibody, AU021329 antibody, AU043350 antibody, AW146323 antibody, BUB 3 antibody, BUB 3L antibody, BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog antibody, bub3 antibody, BUB3 budding uninhibited by benzimidazoles 3 homolog antibody, BUB3 mitotic checkpoint protein antibody, BUB3_HUMAN antibody, BUB3L antibody, Budding uninhibited by benomyl antibody, Budding uninhibited by benzimidazoles 3 antibody, Budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) antibody, Budding uninhibited by benzimidazoles 3 homolog (yeast) antibody, Budding uninhibited by benzimidazoles 3 homolog antibody, Budding uninhibited by benzimidazoles 3, S. cerevisiae, homolog of antibody, C78067 antibody, hBUB3 antibody, Mitotic checkpoint component antibody, Mitotic checkpoint protein bub3 antibody, OTTHUMP00000020679 antibody, OTTHUMP00000020680 antibody, WD repeat type I transmembrane protein A72.5 antibody

UniProt: O43684

Pathways: Maintenance of Protein Location