BIM Antikörper (pSer69)

Produktnummer ABIN7138680

Der Kaninchen-Polyklonal Anti-BIM-Antikörper wurde für IHC, ELISA und IF validiert. Er ist geeignet zum Nachweis von BIM in Proben aus Human. }

Kurzübersicht für BIM Antikörper (pSer69) (ABIN7138680)

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIM Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-BIM Antikörper

Bindungsspezifität: pSer69

Verwendungszweck: Phospho-BCL2L11 (Ser69) Antibody

Kreuzreaktivität: Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 69 (P-A-S(p)-P-G) derived from Human BIM.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BIM

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Andere Bezeichnung: BCL2L11

Hintergrund:

Background: Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-a1, isoform Bim-a2 and isoform Bim-a3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis

Fukazawa H, et al. (2004) Mol Cancer Ther , 3(10): 1281-1288
Luciano F, et al. (2003) Oncogene , 22(43): 6785-6793

Aliases: BCL2 like 11 antibody, B2L11_HUMAN antibody, BAM antibody, Bcl 2 interacting protein Bim antibody, Bcl 2 related ovarian death agonist antibody, Bcl-2-like protein 11 antibody, BCL2 interacting mediator of cell death antibody, BCL2 like 11 (apoptosis facilitator) antibody, BCL2 like protein 11 antibody, Bcl2-interacting mediator of cell death antibody, Bcl2-L-11 antibody, Bcl2l11 antibody, BIM alpha6 antibody, BIM antibody, BIM beta6 antibody, BIM beta7 antibody, BimEL antibody, BimL antibody, BOD antibody

UniProt: O43521

Pathways: PI3K-Akt Signalweg, Neurotrophin Signalübertragung, Tube Formation, Positive Regulation of Endopeptidase Activity