AMPK alpha Antikörper (pSer487)

Produktnummer ABIN7138633

Dieses Anti-AMPK alpha-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von AMPK alpha in WB, IHC, ELISA und IF. Geeignet für Human.

Kurzübersicht für AMPK alpha Antikörper (pSer487) (ABIN7138633)

Target: AMPK alpha (SNF1A) (SNF1A/AMP-Activated Protein Kinase (SNF1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AMPK alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-AMPK alpha Antikörper

Bindungsspezifität: pSer487

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 487 (S-G- SP-V-S) derived from Human AMPKa1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu AMPK alpha

Target: AMPK alpha (SNF1A) (SNF1A/AMP-Activated Protein Kinase (SNF1A))

Andere Bezeichnung: PRKAA1/PRKAA2

Hintergrund:

Background:

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Kim JE, et al. (2005) J Proteome Res. 4(4): 1339-1346.
Woods A, et al. (2003) J Biol Chem. 278(31): 28434-28442.

Aliases: 5 AMP activated protein kinase alpha 1catalytic subunit antibody, 5 AMP activated protein kinase catalytic alpha 1 chain antibody, 5' AMP activated protein kinase catalytic subunit alpha 1 antibody, 5'-AMP-activated protein kinase catalytic subunit alpha-1 antibody, AAPK1 antibody, AAPK1_HUMAN antibody, ACACA kinase antibody, acetyl CoA carboxylase kinase antibody, AI194361 antibody, AI450832 antibody, AL024255 antibody, AMP -activate kinase alpha 1 subunit antibody, AMP-activate kinase alpha 1 subunit antibody, AMP-activated protein kinase, catalytic, alpha -1 antibody, AMPK 1 antibody, AMPK alpha 1 antibody, AMPK alpha 1 chain antibody, AMPK antibody, AMPK subunit alpha 1 antibody, AMPK subunit alpha-1 antibody, AMPK1 antibody, AMPKa1 antibody, AMPKalpha1 antibody, C130083N04Rik antibody, cb116 antibody, EC 2.7.11.1 antibody, HMG CoA reductase kinase antibody, HMGCR kinase antibody, hormone sensitive lipase kinase antibody, Hydroxymethylglutaryl CoA reductase kinase antibody, im:7154392 antibody, kinase AMPK alpha1 antibody, MGC33776 antibody, MGC57364 antibody, OTTHUMP00000161795 antibody, OTTHUMP00000161796 antibody, PRKAA 1 antibody, PRKAA1 antibody, Protein kinase AMP activated alpha 1 catalytic subunit antibody, SNF1-like protein AMPK antibody, SNF1A antibody, Tau protein kinase PRKAA1 antibody, wu:fa94c10 antibody

UniProt: Q13131

Pathways: Warburg Effekt