Vitamin D Receptor Antikörper (pSer208)

Produktnummer ABIN7138475

Produktdetails anti-Vitamin D Receptor Antikörper

Target: Vitamin D Receptor (VDR)

Bindungsspezifität: pSer208

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Vitamin D Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 208 (A-L-S(p)-P-V) derived from Human Vitamin D Receptor.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Andere Bezeichnung: VDR (VDR Produkte)

Substanzklasse: Chemical

Hintergrund:

Background:

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

Arriagada G, et al. (2007) J Steroid Biochem Mol Biol 103, 425-9. Jurutka PW, et al. (1996)Proc Natl Acad Sci U S A 93, 3519-24. Jurutka PW, et al. (1993)J Biol Chem 268, 6791-9.

Aliases: 1 25 dihydroxyvitamin D3 receptor antibody, 1 antibody, 1,25 dihydroxyvitamin D3 receptor antibody, 1,25-@dihydroxyvitamin D3 receptor antibody, 25-dihydroxyvitamin D3 receptor antibody, Member 1 antibody, NR1I1 antibody, Nuclear receptor subfamily 1 group I member 1 antibody, PPP1R163 antibody, Protein phosphatase 1, regulatory subunit 163 antibody, VDR antibody, VDR_HUMAN antibody, Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody, Vitamin D hormone receptor antibody, Vitamin D nuclear receptor variant 1 antibody, Vitamin D receptor antibody, Vitamin D3 receptor antibody

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway