PRKAB1 Antikörper (pSer181)

Produktnummer ABIN7138455

Der Kaninchen-Polyklonal Anti-PRKAB1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet zum Nachweis von PRKAB1 in Proben aus Human. }

Kurzübersicht für PRKAB1 Antikörper (pSer181) (ABIN7138455)

Target: PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKAB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PRKAB1 Antikörper

Bindungsspezifität: pSer181

Verwendungszweck: Phospho-PRKAB1 (Ser181) Antibody

Kreuzreaktivität: Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 181(L-S-S(p)-S-P) derived from Human AMPK beta1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRKAB1

Target: PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))

Andere Bezeichnung: PRKAB1

Hintergrund:

Background: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Aliases: 1300015D22Rik antibody, 5''-AMP-activated protein kinase subunit beta-1 antibody, 5'-AMP-activated protein kinase beta-1 subunit antibody, AAKB1_HUMAN antibody, AMP-activated protein kinase beta subunit antibody, AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1 antibody, AMP-activated, noncatalytic, beta-1 antibody, AMPK antibody, AMPK beta 1 chain antibody, AMPK subunit beta-1 antibody, AMPK-BETA-1 antibody, AMPKb antibody, AU021155 antibody, E430008F22 antibody, HAMPKb antibody, MGC17785 antibody, PRKAB1 antibody, Protein kinase AMP activated non catalytic subunit beta 1 antibody, protein kinase, AMP-activated, beta 1 non-catalytic subunit antibody, protein kinase, AMP-activated, noncatalytic, beta-1 antibody

UniProt: Q9Y478

Pathways: AMPK Signaling, Warburg Effekt