MAP2K5 Antikörper

Produktnummer ABIN7137963

Der Kaninchen Polyklonal Anti-MAP2K5-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, MAP2K5 in Proben von Ratte zu detektieren.

Kurzübersicht für MAP2K5 Antikörper (ABIN7137963)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MAP2K5 Antikörper

Verwendungszweck: Map2k5 Antibody

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around aa. 311-315(K-T-Y-V-G ) derived from Rat MEK5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Andere Bezeichnung: Map2k5

Hintergrund:

Background: A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7)phosphorylates and activates the JNK signal transduction pathway.

Han, J., et al. 1996. J. Biol. Chem. 271: 2886-2891.
Jiang, Y., et al. 1996. J. Biol. Chem. 271: 17920-17926.
Tournier, C., et al. 1997. Proc. Natl. Acad. Sci. USA94: 7337-7442.
Holland, P.M., et al. 1997. J. Biol. Chem. 272: 24994-24998.

Aliases: Map2k5 antibody, Mek5 antibody, Mkk5 antibody, Prkmk5 antibody, Dual specificity mitogen-activated protein kinase kinase 5 antibody, MAP kinase kinase 5 antibody, MAPKK 5 antibody, EC 2.7.12.2 antibody, MAPK/ERK kinase 5 antibody, MEK 5 antibody

UniProt: Q62862

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung