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LIN28A Antikörper (AA 1-5)

Der Kaninchen Polyklonal Anti-LIN28A-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, LIN28A in Proben von Human zu detektieren.
Produktnummer ABIN7137921

Kurzübersicht für LIN28A Antikörper (AA 1-5) (ABIN7137921)

Target

Alle LIN28A Antikörper anzeigen
LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Reaktivität

  • 98
  • 31
  • 28
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 83
  • 19
Kaninchen

Klonalität

  • 77
  • 25
Polyklonal

Konjugat

  • 52
  • 7
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LIN28A Antikörper ist unkonjugiert

Applikation

  • 66
  • 38
  • 26
  • 23
  • 19
  • 14
  • 13
  • 13
  • 11
  • 10
  • 9
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 15
    • 9
    • 9
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-5

    Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

    Immunogen

    Peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Human Lin28

    Isotyp

    IgG
  • Applikationshinweise

    WB:1:500-1:1000,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

    Andere Bezeichnung

    LIN28A

    Hintergrund

    Background: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.

    Heo I., Joo C., Mol. et al., Cell 32:276-284(2008)
    Heo I., Joo C., Kim Y.-K., et al., Cell 138:696-708(2009)
    Viswanathan S.R., Powers J.T., et al., Nat. Genet. 41:843-848(2009)

    Aliases: AL024421 antibody, CSDD1 antibody, CSDD2 antibody, FLJ12457 antibody, Lin 28 antibody, Lin 28 homolog (C. elegans) antibody, Lin 28 homolog A (C. elegans) antibody, Lin 28 homolog A antibody, Lin 28 homolog antibody, Lin-28A antibody, Lin28 antibody, Lin28, C. elegans, homolog of, A antibody, LIN28A antibody, LN28A_HUMAN antibody, Protein lin-28 homolog A antibody, Protein lin-28 homolog B antibody, RNA binding protein lin 28 antibody, Tex17 antibody, ZCCHC1 antibody, Zinc finger CCHC domain containing 1 antibody, Zinc finger CCHC domain containing protein 1 antibody, Zinc finger CCHC domain-containing protein 1 antibody

    UniProt

    Q9H9Z2

    Pathways

    Stem Cell Maintenance
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