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Rekombinanter PELP1 Antikörper

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch PELP1 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7127675

Kurzübersicht für Rekombinanter PELP1 Antikörper (ABIN7127675)

Target

Alle PELP1 Antikörper anzeigen
PELP1 (Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 44
  • 37
  • 12
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 44
  • 8
Kaninchen

Klonalität

  • 40
  • 12
Monoklonal

Konjugat

  • 28
  • 5
  • 4
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PELP1 Antikörper ist unkonjugiert

Applikation

  • 35
  • 30
  • 16
  • 7
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon

6H4
  • Kreuzreaktivität

    Human

    Aufreinigung

    Affinity-chromatography

    Immunogen

    A synthesized peptide derived from human PELP1

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    PELP1 (Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1))

    Andere Bezeichnung

    PELP1

    Hintergrund

    Background: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

    Aliases: Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3), PELP1, HMX3 MNAR

    UniProt

    Q8IZL8
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