Rekombinanter SIN3A Antikörper

Produktnummer ABIN7127630

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch SIN3A in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter SIN3A Antikörper (ABIN7127630)

Target: SIN3A (SIN3 homolog A, transcription regulator (SIN3A))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SIN3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: 10G3

Produktdetails anti-SIN3A Antikörper

Verwendungszweck: SIN3A Recombinant Monoclonal Antibody

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human mSin3A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SIN3A

Target: SIN3A (SIN3 homolog A, transcription regulator (SIN3A))

Andere Bezeichnung: SIN3A

Hintergrund:

Background: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).

Aliases: Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a), SIN3A

UniProt: Q96ST3

Pathways: Activation of Innate immune Response, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha