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Rekombinanter FGFR4 Antikörper

Dieses Anti-FGFR4-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von FGFR4 in ELISA und IHC. Geeignet für Human.
Produktnummer ABIN7127491

Kurzübersicht für Rekombinanter FGFR4 Antikörper (ABIN7127491)

Target

Alle FGFR4 Antikörper anzeigen
FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 88
  • 37
  • 26
  • 1
  • 1
Human

Wirt

  • 72
  • 18
  • 2
  • 1
Kaninchen

Klonalität

  • 66
  • 24
  • 2
Monoklonal

Konjugat

  • 50
  • 8
  • 7
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FGFR4 Antikörper ist unkonjugiert

Applikation

  • 53
  • 40
  • 23
  • 22
  • 13
  • 13
  • 12
  • 11
  • 7
  • 6
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
ELISA, Immunohistochemistry (IHC)

Klon

8A5
  • Kreuzreaktivität

    Human

    Aufreinigung

    Affinity-chromatography

    Immunogen

    A synthesized peptide derived from human FGFR4

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: IHC:1:50-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

    Andere Bezeichnung

    FGFR4

    Hintergrund

    Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

    Aliases: Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334), FGFR4, JTK2 TKF

    UniProt

    P22455

    Pathways

    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding
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