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Rekombinanter FGFR4 Antikörper

FGFR4 Reaktivität: Human ELISA, IHC Wirt: Kaninchen Monoclonal 8A5 unconjugated Recombinant Antibody
Produktnummer ABIN7127491
  • Target Alle FGFR4 Antikörper anzeigen
    FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 88
    • 37
    • 26
    • 1
    • 1
    Human
    Wirt
    • 72
    • 18
    • 2
    • 1
    Kaninchen
    Klonalität
    • 66
    • 24
    • 2
    Monoklonal
    Konjugat
    • 50
    • 8
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FGFR4 Antikörper ist unkonjugiert
    Applikation
    • 53
    • 40
    • 23
    • 22
    • 13
    • 13
    • 12
    • 11
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human FGFR4
    Klon
    8A5
    Isotyp
    IgG
    Top Product
    Discover our top product FGFR4 Primärantikörper
  • Applikationshinweise
    Recommended dilution: IHC:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
    Andere Bezeichnung
    FGFR4 (FGFR4 Produkte)
    Hintergrund

    Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

    Aliases: Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334), FGFR4, JTK2 TKF

    UniProt
    P22455
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding
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