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Rekombinanter S1PR1 Antikörper

Der Kaninchen Monoklonal Anti-S1PR1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, S1PR1 in Proben von Human zu detektieren.
Produktnummer ABIN7127463

Kurzübersicht für Rekombinanter S1PR1 Antikörper (ABIN7127463)

Target

Alle S1PR1 Antikörper anzeigen
S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 99
  • 65
  • 43
  • 7
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 97
  • 11
Kaninchen

Klonalität

  • 87
  • 21
Monoklonal

Konjugat

  • 61
  • 5
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser S1PR1 Antikörper ist unkonjugiert

Applikation

  • 79
  • 40
  • 18
  • 18
  • 14
  • 14
  • 13
  • 11
  • 7
  • 7
  • 3
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB), ELISA

Klon

4F2
  • Kreuzreaktivität

    Human

    Aufreinigung

    Affinity-chromatography

    Immunogen

    A synthesized peptide derived from human EDG1

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:500-1:5000,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

    Andere Bezeichnung

    S1PR1

    Hintergrund

    Background: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

    Aliases: Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363), S1PR1, CHEDG1 EDG1

    UniProt

    P21453

    Pathways

    Signaling Events mediated by VEGFR1 and VEGFR2
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