Syndecan 1 Antikörper (AA 90-250)

Produktnummer ABIN7126924

Produktdetails anti-Syndecan 1 Antikörper

Target: Syndecan 1 (SDC1)

Bindungsspezifität: AA 90-250

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Syndecan 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa90-250) of human CD138 protein (exact sequence is proprietary)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human tonsil or lymph node.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Syndecan 1

Target: Syndecan 1 (SDC1)

Andere Bezeichnung: SDC1 (SDC1 Produkte)

Synonyme: CG10497 antikoerper, CT27296 antikoerper, Dmel\\CG10497 antikoerper, Dsyn antikoerper, Syd antikoerper, Syn antikoerper, dSdc antikoerper, l(2)10608 antikoerper, sdc antikoerper, syd antikoerper, syn antikoerper, Syn1 antikoerper, cd138 antikoerper, synd1 antikoerper, xSyn1 antikoerper, syndecan1 antikoerper, Syndecan-1 antikoerper, XSyndecan-1 antikoerper, SDC1 antikoerper, CD138 antikoerper, SDC antikoerper, SYND1 antikoerper, syndecan antikoerper, AA408134 antikoerper, AA409076 antikoerper, Sstn antikoerper, Synd antikoerper, Synd1 antikoerper, syn-1 antikoerper, HSPG antikoerper, SYNDECA antikoerper, Syndecan antikoerper, Syndecan antikoerper, syndecan 1 antikoerper, Sdc antikoerper, sdc1 antikoerper, SDC1 antikoerper, Sdc1 antikoerper

Hintergrund: Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor, SDC1, SYND1, Syndecan Proteoglycan 1, Syndecan-1,CD138 / Syndecan-1 (SDC1) (Plasma Cell Marker)
Cellular localisation: Cell Surface

Molekulargewicht: 85kDa

Gen-ID: 6382, 224607

UniProt: P18827

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism