Retinoid X Receptor gamma Antikörper

Produktnummer ABIN7126908

Produktdetails anti-Retinoid X Receptor gamma Antikörper

Target: Retinoid X Receptor gamma (RXRG) (Retinoid X Receptor, gamma (RXRG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoid X Receptor gamma Antikörper ist unkonjugiert

Applikation: ELISA, Immunoprecipitation (IP), Coating (Coat), Flow Cytometry (FACS)

Spezifität: Two families of retinoid receptors, RARs and RXRs, have been identified. Retinoic acid receptors (RARs) include RARa, RARb and RARg, each of which have a high affinity for all trans-retinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand-binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns throughout development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXRi±, RXRi² and RXRi³, are activated by 9-cis-RA, a stereo- and photo-isomer of all trans-RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone. As is true for the RAR subfamily, the RXR receptors are closely related to each other both in their DNA-binding and ligand-binding domains and are encoded by separate genes at distinct chromosomal loci.

Kreuzreaktivität (Details): Human. Predicted to react in Mouse, Rat and Chick.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human RXRG protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), ,Optimal dilution for a specific application should be determined.

Positive_Control: SK-MEL-30, U-2 OS or HeLa cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Retinoid X Receptor gamma

Target: Retinoid X Receptor gamma (RXRG) (Retinoid X Receptor, gamma (RXRG))

Andere Bezeichnung: RXRG (RXRG Produkte)

Hintergrund: Nuclear receptor subfamily 2 group B member 3 (NR2B3), Retinoic X receptor gamma (RXRG), Retinoic acid receptor RXR gamma, RXR gamma, RXRC,RXRG / NR2B3 (Transcription Factor)
Cellular localisation: Nucleus > Nucleoplasm > Nuclear bodies.

Molekulargewicht: 50.87kDa

Gen-ID: 6258, 26550

UniProt: P48443

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway