Rekombinanter RRM1 Antikörper (AA 700-800)

Produktnummer ABIN7126906

Dieses Anti-RRM1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von RRM1 in IHC (f). Geeignet für Human.

Kurzübersicht für Rekombinanter RRM1 Antikörper (AA 700-800) (ABIN7126906)

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser RRM1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Produktdetails anti-RRM1 Antikörper

Bindungsspezifität: AA 700-800

Spezifität: Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Synthetic peptide corresponding to residues within aa700-800 of human RRM1 (exact sequence is proprietary)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human breast, lung or colon carcinoma tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu RRM1

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Andere Bezeichnung: RRM1

Hintergrund: Ribonucleoside diphosphate reductase large subunit, Ribonucleoside diphosphate reductase M1 chain, RR1, RRM1, RIR1, Ribonucleotide reductase M1 polypeptide, Ribonucleotide reductase R1 subunit,Ribonucleotide Reductase M1 / RRM1
Cellular localisation: Cytoplasm

Molekulargewicht: 94kDa

Gen-ID: 6240, 445705

Pathways: Positive Regulation of Endopeptidase Activity