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Rekombinanter POMC Antikörper (AA 1-24)

Dieses Anti-POMC-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von POMC in IHC (f). Geeignet für Human.
Produktnummer ABIN7126807

Kurzübersicht für Rekombinanter POMC Antikörper (AA 1-24) (ABIN7126807)

Target

Alle POMC Antikörper anzeigen
POMC (Proopiomelanocortin (POMC))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 70
  • 43
  • 42
  • 6
  • 1
  • 1
Human

Wirt

  • 65
  • 36
  • 1
Maus

Klonalität

  • 64
  • 38
Monoklonal

Konjugat

  • 70
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser POMC Antikörper ist unkonjugiert

Applikation

  • 43
  • 40
  • 32
  • 29
  • 20
  • 18
  • 17
  • 13
  • 13
  • 13
  • 11
  • 7
  • 5
  • 5
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
  • Bindungsspezifität

    • 16
    • 10
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-24

    Spezifität

    ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH), does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

    Kreuzreaktivität (Details)

    Human.

    Aufreinigung

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    Immunogen

    Synthetic peptide corresponding to aa1-24 of human ACTH

    Isotyp

    IgG2a
  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: Normal pituitary gland or pituitary tumor.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    Konservierungsmittel

    Azide free

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    Haltbarkeit

    24 months
  • Target

    POMC (Proopiomelanocortin (POMC))

    Andere Bezeichnung

    POMC

    Hintergrund

    Adrenocorticotropin, alpha, beta or gamma Melanocyte Stimulating Hormone (MSH) or Melanotropin, beta Endorphin, beta or gamma Lipotropin (LPH), CLIP, Met Enkephalin, POC, POMC,ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker)
    Cellular localisation: Cytoplasm.

    Molekulargewicht

    ACTH is ~5kDa, and the POMC precursor is ~30kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.

    Gen-ID

    5443, 1897

    UniProt

    P01189

    Pathways

    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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