Rekombinanter Interferon gamma Antikörper

Produktnummer ABIN7126539

Der Maus Monoklonal Anti-Interferon gamma-Antikörper wurde für IHC (f) validiert. Er ist geeignet, Interferon gamma in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter Interferon gamma Antikörper (ABIN7126539)

Target: Interferon gamma (IFNG)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Interferon gamma Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Produktdetails anti-Interferon gamma Antikörper

Spezifität: Recognizes a protein of 20-25 kDa, identified as human interferon. This MAb is specific to human IFN-i³, and recognizes both recombinant and native human IFN-gamma. T lymphocytes and NK cells mainly produce IFN-i³. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak anti-viral and anti-proliferative activity, and potentiates the antiviral and anti-tumor effects of IFN-i±/i² (type I interferon).

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Purified recombinant human full-length IFNG protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: PMA stimulated human peripheral blood mononuclear cells. Renal or testicular carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Interferon gamma

Target: Interferon gamma (IFNG)

Andere Bezeichnung: IFNG

Hintergrund: AMCF1, Beta thromboglobulin like protein, CXC chemokine ligand 8 (CXCL8), Emoctakin, Granulocyte chemotactic protein 1 (GCP1), IFG, IFI, IFN Immune, IFN-gamma (IFNG), Interleukin 8, Interferon gamma, LECT, LUCT, Lymphocyte derived neutrophil activating factor, LYNAP, Macrophage Activating Factor (MAF), Monocyte derived neutrophil activating protein (MONAP), Monocyte derived neutrophil chemotactic factor (MDNCF), Neutrophil activating factor (NAF), Neutrophil activating peptide 1 (NAP1), Neutrophil activating protein 1 (NAP1), SCYB8, T cell chemotactic factor, T Cell Interferon,Interferon gamma (IFNG)
Cellular localisation: Cytoplasmic & Cell Surface

Molekulargewicht: 20-25kDa

Gen-ID: 3458, 856

UniProt: P01579

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie