TOX3 Antikörper (AA 251-389)

Produktnummer ABIN7126479

Der Maus Monoklonal Anti-TOX3-Antikörper wurde für WB, ELISA, IHC und Coat validiert. Er ist geeignet, TOX3 in Proben von Human zu detektieren.

Kurzübersicht für TOX3 Antikörper (AA 251-389) (ABIN7126479)

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TOX3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Coating (Coat)

Produktdetails anti-TOX3 Antikörper

Bindungsspezifität: AA 251-389

Spezifität: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order Ab without BSA), Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.

Positive_Control: A431 cell lysate (WB). Human breast or gastric carcinoma (IHC).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu TOX3

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Andere Bezeichnung: TOX3

Hintergrund: TOX3, CAG trinucleotide repeat-containing gene F9 protein, CAGF9, TOX high mobility group box family member 3, Trinucleotide repeat containing 9 (TNRC9),TOX3 / TNRC9
Cellular localisation: Cytoplasmic & Nuclear

Molekulargewicht: 63kDa

Gen-ID: 27324, 460789

UniProt: O15405

Pathways: Chromatin Binding