Rekombinanter AMH Antikörper (C-Term)

Produktnummer ABIN7126472

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch AMH in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter AMH Antikörper (C-Term) (ABIN7126472)

Target: AMH (Anti-Mullerian Hormone (AMH))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser AMH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: AMH-6713R

Produktdetails anti-AMH Antikörper

Bindungsspezifität: AA 460-560, C-Term

Verwendungszweck: Recombinant Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS) Antibody

Spezifität: The transforming growth factor æ (TGF æ) superfamily is composed of numerous growth and differentiation factors, including TGF æ1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin °™, æ-A, æ-B and æ-C, Lefty and Nodal. Members of the TGF æ superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Kreuzreaktivität (Details): Human.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Synthetic peptide from the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human ovary or testis.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Andere Bezeichnung: AMH

Hintergrund:

Muellerian inhibiting factor (MIF)

Human ovary or testis.

Molekulargewicht: 70kDa (reduced), 140kDa (nonreduced)

Gen-ID: 268, 112432

Pathways: Negative Regulation of Hormone Secretion