Endoglin Antikörper

Produktnummer ABIN7126335

Der Maus Monoklonal Anti-Endoglin-Antikörper wurde für FACS, ELISA, IF, Func und Coat validiert. Er ist geeignet, Endoglin in Proben von Human zu detektieren.

Kurzübersicht für Endoglin Antikörper (ABIN7126335)

Target: Endoglin (ENG)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Endoglin Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Functional Studies (Func), Coating (Coat)

Produktdetails anti-Endoglin Antikörper

Spezifität: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

Kreuzreaktivität (Details): Human, Monkey, Horse, Pig and Rat.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant extracellular fragment of human Endoglin protein exact sequence is proprietary)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), Functional Assays (order antibody without BSA and azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (2-4 μg/mL) Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, A431 or HL-60 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Endoglin

Target: Endoglin (ENG)

Andere Bezeichnung: ENG

Hintergrund: CD105, END, Endoglin, Eng, HHT1, S-endoglin,Endoglin / CD105 (Angiogenesis Marker)
Cellular localisation: Cell Surface

Molekulargewicht: 80kDa (Monomer), 160kDa (Homodimer)

Gen-ID: 2022, 76753

UniProt: P17813