Clusterin Antikörper (AA 185-287)
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- Target Alle Clusterin (CLU) Antikörper anzeigen
- Clusterin (CLU)
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Bindungsspezifität
- AA 185-287
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Clusterin Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, i± and i², are associated through disulfide bonds. The i² subunit (also called ApoJi±) corresponds to residues 23-227. The i± subunit (also called ApoJi²) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences i²-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa185-287) of human NPM1 protein (exact sequence is proprietary)
- Isotyp
- IgG2b
- Top Product
- Discover our top product CLU Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human pancreas, tonsil or cervix.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- Clusterin (CLU)
- Andere Bezeichnung
- CLU (CLU Produkte)
- Synonyme
- LOC100136120 antikoerper, clu antikoerper, MGC53055 antikoerper, zgc:73352 antikoerper, xclu antikoerper, MGC89163 antikoerper, CLU antikoerper, APO-J antikoerper, APOJ antikoerper, CLI antikoerper, CLU1 antikoerper, CLU2 antikoerper, KUB1 antikoerper, NA1/NA2 antikoerper, SGP-2 antikoerper, SGP2 antikoerper, SP-40 antikoerper, TRPM-2 antikoerper, TRPM2 antikoerper, DAG antikoerper, RATTRPM2B antikoerper, SP40 antikoerper, TRPM2B antikoerper, Trpm2 antikoerper, Trpmb antikoerper, AI893575 antikoerper, ApoJ antikoerper, Cli antikoerper, D14Ucla3 antikoerper, Sgp-2 antikoerper, Sgp2 antikoerper, Sugp-2 antikoerper, GP80 antikoerper, gpIII antikoerper, 40 antikoerper, clusterin-1 antikoerper, clusterin L homeolog antikoerper, clusterin antikoerper, Clusterin antikoerper, LOC100136120 antikoerper, clu.L antikoerper, clu antikoerper, CLU antikoerper, clus antikoerper, Clu antikoerper, LOC101113728 antikoerper
- Hintergrund
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Aging associated protein 4, Apolipoprotein J, CLU1, CLU2, Clusterin alpha / beta chain, Complement associated protein SP40, Complement cytolysis inhibitor a chain, NA1/NA2, D14Ucla3, Dimeric acid glycoprotein, GP80, Ku70-binding protein 1 (KUB1), Sulfated glycoprotein 2 (SGP2), Testosterone repressed prostate message 2 (TPRM2B),Clusterin / Apolipoprotein J (APO-J)
Cellular localisation: Cytoplasm and Nucleus. - Molekulargewicht
- 70kDa (precursor), 36-39kDa (i±), 34-36kDa (i²)
- Gen-ID
- 1191, 436657
- UniProt
- P10909
- Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
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