MERTK Antikörper (AA 55-148)

Produktnummer ABIN7126187

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MERTK in IHC und IHC (f). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MERTK Antikörper (AA 55-148) (ABIN7126187)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MERTK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Produktdetails anti-MERTK Antikörper

Bindungsspezifität: AA 55-148

Spezifität: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C i³2 (PI-PLC i³2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

Kreuzreaktivität (Details): Human. Others not known.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human colon tissue (IHC).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Andere Bezeichnung: MERTK

Hintergrund: CEyk, MER receptor tyrosine kinase, MERK, MERPEN, nmf12, Nyk, Proto-oncogene c-Mer, RP38, STK kinase,MerTK (Innate Immune Checkpoint)
Cellular localisation: Cell surface.

Molekulargewicht: 110kDa

Gen-ID: 10461, 306178

UniProt: Q12866

Pathways: RTK Signalweg