YTHDF2 Antikörper

Produktnummer ABIN7120904

Der Kaninchen-Polyklonal Anti-YTHDF2-Antikörper wurde für WB, ELISA, IHC, IF und IP validiert. Er ist geeignet zum Nachweis von YTHDF2 in Proben aus Human, Maus und Ratte. }

Kurzübersicht für YTHDF2 Antikörper (ABIN7120904)

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YTHDF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-YTHDF2 Antikörper

Verwendungszweck: YTHDF2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: YTH domain family, member 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:10000, IF: 1:10-1:100, IP: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu YTHDF2

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Andere Bezeichnung: YTHDF2

Hintergrund:

Synonyms: YTH domain-containing family protein 2 (DF2)|CLL-associated antigen KW-14|High-glucose-regulated protein 8|Renal carcinoma antigen NY-REN-2|YTHDF2|HGRG8

Background: Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, and regulates mRNA stability(PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies(P-bodies), leading to mRNA degradation(PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation(PubMed:26458103).

Molekulargewicht: 68 kDa

Gen-ID: 51441

UniProt: Q9Y5A9