WTAP Antikörper (AA 1-150)

Produktnummer ABIN7120845

Dieses Anti-WTAP-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von WTAP in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für WTAP Antikörper (AA 1-150) (ABIN7120845)

Target: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser WTAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Klon: 9D4

Produktdetails anti-WTAP Antikörper

Bindungsspezifität: AA 1-150

Verwendungszweck: WTAP antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-150aa

Immunogen: Wilms tumor 1 associated protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:10000, IHC: 1:50-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu WTAP

Target: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Andere Bezeichnung: WTAP

Hintergrund:

Synonyms: Pre-mRNA-splicing regulator WTAP|Female-lethal(2)D homolog (hFL(2)D)|WT1-associated protein|Wilms tumor 1-associating protein|WTAP|KIAA0105

Background: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).

Molekulargewicht: 49 kDa

Gen-ID: 9589

UniProt: Q15007