UPF3B Antikörper

Produktnummer ABIN7120629

Dieser Anti-UPF3B-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von UPF3B in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für UPF3B Antikörper (ABIN7120629)

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UPF3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-UPF3B Antikörper

Verwendungszweck: UPF3B antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: UPF3 regulator of nonsense transcripts homolog B(yeast)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IHC:1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu UPF3B

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Andere Bezeichnung: UPF3B

Hintergrund:

Synonyms: Regulator of nonsense transcripts 3B|Nonsense mRNA reducing factor 3B|Up-frameshift suppressor 3 homolog B (hUpf3B)|Up-frameshift suppressor 3 homolog on chromosome X (hUpf3p-X)|UPF3B|RENT3B|UPF3X

Background: Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation, the function is independent of association with UPF2 and components of the EJC core.

Molekulargewicht: 58 kDa

Gen-ID: 65109

UniProt: Q9BZI7