FAS Antikörper (AA 156-335)

Produktnummer ABIN7119981

Dieses Anti-FAS-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von FAS in WB, FACS, IHC und ELISA. Geeignet für Human und Maus.

Kurzübersicht für FAS Antikörper (AA 156-335) (ABIN7119981)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA

Klon: 4B6

Produktdetails anti-FAS Antikörper

Bindungsspezifität: AA 156-335

Verwendungszweck: FAS antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 156-335aa

Immunogen: Fas(TNF receptor superfamily, member 6)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:8000, IHC: 1:50-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: FAS

Hintergrund:

Synonyms: Tumor necrosis factor receptor superfamily member 6|Apo-1 antigen|Apoptosis-mediating surface antigen FAS|FASLG receptor|FAS|APT1|FAS1|TNFRSF6

Background: Fas(CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.

Molekulargewicht: 38-45 kDa

Gen-ID: 355

UniProt: P25445

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity