TIMELESS Antikörper

Produktnummer ABIN7119971

Der Kaninchen Polyklonal Anti-TIMELESS-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, TIMELESS in Proben von Human und Maus zu detektieren.

Kurzübersicht für TIMELESS Antikörper (ABIN7119971)

Target: TIMELESS (Timeless Homolog (TIMELESS))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMELESS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TIMELESS Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: timeless homolog(Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Andere Bezeichnung: TIMELESS

Hintergrund: Synonyms:FLJ12640, FLJ20714, hTIM, Protein timeless homolog, TIM, TIM1, TIMELESS, timeless homolog(Drosophila), TIMELESS1 Background:Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

Molekulargewicht: 140kd

Gen-ID: 8914

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism