SREBF chaperone Antikörper
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- Target Alle SREBF chaperone (SCAP) Antikörper anzeigen
- SREBF chaperone (SCAP)
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SREBF chaperone Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Aufreinigung
- Immunogen affinity purified
- Reinheit
- ≥95 % as determined by SDS-PAGE
- Immunogen
- SREBF chaperone
- Isotyp
- IgG
- Top Product
- Discover our top product SCAP Primärantikörper
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anti-SREBF chaperone (SCAP) (AA 604-632) antibody
SCAP Reaktivität: Human, Maus, Ratte WB, IF, IHC (p), FACS Wirt: Kaninchen Polyclonal RB22508 unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP Reaktivität: Human WB, IHC, FACS, IF/ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SREBF chaperone (SCAP) (AA 49-83), (N-Term) antibodySCAP Reaktivität: Human WB Wirt: Maus Monoclonal 1992C245-37-16 unconjugated
anti-SREBF chaperone (SCAP) (AA 977-1194) antibodySCAP Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Haltbarkeit
- 12 months
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- Target
- SREBF chaperone (SCAP)
- Andere Bezeichnung
- SCAP (SCAP Produkte)
- Hintergrund
- Synonyms:KIAA0199 Background:Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway(By similarity).SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt: Q12770).
- Molekulargewicht
- 140 kDa,96 kDa
- Gen-ID
- 22937
- UniProt
- Q12770
- Pathways
- SARS-CoV-2 Protein Interaktom
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