SSTR2 Antikörper
Kurzübersicht für SSTR2 Antikörper (ABIN7119337)
Target
Alle SSTR2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- SSTR2 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- somatostatin receptor 2
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:1000, IHC: 1:50-1:100
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- SSTR2 (Somatostatin Receptor 2 (SSTR2))
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Andere Bezeichnung
- SSTR2
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Hintergrund
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Synonyms: Somatostatin receptor type 2 (SS-2-R, SS2-R, SS2R, SST2)|SRIF-1|SSTR2
Background: Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
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Molekulargewicht
- 41 kDa
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Gen-ID
- 6752
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UniProt
- P30874
Target
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