SRGAP2 Antikörper (AA 780-940)

Produktnummer ABIN7119134

Der Kaninchen Polyklonal Anti-SRGAP2-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, SRGAP2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für SRGAP2 Antikörper (AA 780-940) (ABIN7119134)

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRGAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SRGAP2 Antikörper

Bindungsspezifität: AA 780-940

Verwendungszweck: SRGAP2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 780-940aa

Immunogen: SLIT-ROBO Rho GTPase activating protein 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu SRGAP2

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Andere Bezeichnung: SRGAP2

Hintergrund:

Synonyms: SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2)|Formin-binding protein 2|Rho GTPase-activating protein 34|SRGAP2|ARHGAP34|FNBP2|KIAA0456|SRGAP2A

Background: RAC1 GTPase activating protein(GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Molekulargewicht: 120-140 kDa

Gen-ID: 23380

UniProt: O75044