SETD2 Antikörper (AA 2475-2564)

Produktnummer ABIN7118991

Dieses Anti-SETD2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SETD2 in WB, IHC, ELISA und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für SETD2 Antikörper (AA 2475-2564) (ABIN7118991)

Target: SETD2 (SET Domain Containing 2 (SETD2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-SETD2 Antikörper

Bindungsspezifität: AA 2475-2564

Verwendungszweck: SETD2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 2475-2564aa

Immunogen: SET domain containing 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu SETD2

Target: SETD2 (SET Domain Containing 2 (SETD2))

Andere Bezeichnung: SETD2

Hintergrund:

Synonyms: Histone-lysine N-methyltransferase SETD2|HIF-1|Huntingtin yeast partner B|Huntingtin-interacting protein 1 (HIP-1)|Huntingtin-interacting protein B|Lysine N-methyltransferase 3A|Protein-lysine N-methyltransferase SETD2|SET domain-containing protein 2 (hSET2)|p231HBP|SETD2|HIF1|HYPB|KIAA1732|KMT3A|SET2

Background: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3(H3K36me3) using dimethylated 'Lys-36'(H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.

Molekulargewicht: 287 kDa

Gen-ID: 29072

UniProt: Q9BYW2

Pathways: Tube Formation