Septin 2 Antikörper

Produktnummer ABIN7118880

Dieses Anti-Septin 2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Septin 2 in WB, ELISA, IHC und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Septin 2 Antikörper (ABIN7118880)

Target: Septin 2 (SEPT2)

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Septin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: 8H4

Produktdetails anti-Septin 2 Antikörper

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: septin 2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:20000-1:200000, IHC: 1:50-1:2000, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu Septin 2

Target: Septin 2 (SEPT2)

Andere Bezeichnung: SEPT2

Hintergrund: Synonyms:hNedd5, NEDD 5, NEDD5, SEPT2, SEPT2/septin 2, septin 2, septin2 Background:Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex(also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Molekulargewicht: 43 kDa

Gen-ID: 4735

UniProt: Q15019