RFFL Antikörper

Produktnummer ABIN7118629

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RFFL in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für RFFL Antikörper (ABIN7118629)

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFFL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RFFL Antikörper

Verwendungszweck: RFFL antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger and FYVE-like domain containing 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RFFL

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Andere Bezeichnung: RFFL

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase rififylin|Caspase regulator CARP2|Caspases-8 and -10-associated RING finger protein 2 (CARP-2)|FYVE-RING finger protein Sakura (Fring)|RING finger and FYVE-like domain-containing protein 1|RING finger protein 189|RING finger protein 34-like|RING-type E3 ubiquitin transferase rififylin|RFFL|RNF189|RNF34L

Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.

Molekulargewicht: 37-41 kDa

Gen-ID: 117584

UniProt: Q8WZ73