ARHGEF1 Antikörper (AA 27-84)
Kurzübersicht für ARHGEF1 Antikörper (AA 27-84) (ABIN7118488)
Target
Alle ARHGEF1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 27-84
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Verwendungszweck
- ARHGEF1 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
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Immunogen sequence: 27-84aa
Immunogen: Rho guanine nucleotide exchange factor(GEF) 1
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- ARHGEF1 (rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1))
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Andere Bezeichnung
- ARHGEF1
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Hintergrund
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Synonyms: Rho guanine nucleotide exchange factor 1|115 kDa guanine nucleotide exchange factor (p115-RhoGEF, p115RhoGEF)|Sub1.5|ARHGEF1
Background: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12(GNA12) and alpha-13(GNA13) subunits. Acts as GTPase-activating protein(GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor(GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
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Molekulargewicht
- 102-110 kDa
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Gen-ID
- 9138
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UniProt
- Q92888
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Pathways
- Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling
Target
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