RGMA Antikörper

Produktnummer ABIN7118468

Der Kaninchen Polyklonal Anti-RGMA-Antikörper wurde für WB, ELISA und IP validiert. Er ist geeignet, RGMA in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für RGMA Antikörper (ABIN7118468)

Target: RGMA (RGM Domain Family, Member A (RGMA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Produktdetails anti-RGMA Antikörper

Verwendungszweck: RGMA antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: RGM domain family, member A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RGMA

Target: RGMA (RGM Domain Family, Member A (RGMA))

Andere Bezeichnung: RGMA

Hintergrund:

Synonyms: Repulsive guidance molecule A|RGM domain family member A|RGMA|RGM

Background: Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Molekulargewicht: 49 kDa

Gen-ID: 56963

UniProt: Q96B86

Pathways: Tube Formation