RGMA Antikörper (Extracellular, N-Term, Prodomain)

Produktnummer ABIN7886669

Der Kaninchen Polyklonal anti-RGMA Antikörper (ABIN7886669) detektiert spezifisch RGMA in WB, IHC, FACS und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für RGMA Antikörper (Extracellular, N-Term, Prodomain) (ABIN7886669)

Target: RGMA (RGM Domain Family, Member A (RGMA))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-RGMA Antikörper

Bindungsspezifität: AA 138-154, Extracellular, N-Term, Prodomain

Verwendungszweck: A Rabbit polyclonal antibody to RGMA (extracellular).

Sequenz: (C)ERSDSPEI(S)HYEKSFHK

Homologie: Mouse,human,rat - 16 out of 17 amino acid identical

Produktmerkmale: Anti-RGMA (extracellular) Antibody (ABIN7581951) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize RGMA from mouse, rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)ERSDSPEI(S)HYEKSFHK, corresponding to amino acid residues 138 - 154 of mouse RGMA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu RGMA

Target: RGMA (RGM Domain Family, Member A (RGMA))

Andere Bezeichnung: RGMA

Hintergrund:

Synonyms: Repulsive Guidance Molecule A, RGM Domain Family Member A, Repulsive Guidance Molecule BMP Co-Receptor A, RGMa

Description: Repulsive Guidance Molecule A (RGMA) is a member of the RGM family, which also includes RGMb (DRAGON) and RGMc (hemojuvelin). It is a glycosylphosphatidylinositol (GPI)-anchored protein characterized by a von Willebrand factor type D domain and a GPI-anchor, facilitating membrane association and soluble forms1,2. This dual functional nature enables RGMA to act both as a localized, membrane-bound signal and as a long-range soluble signaling molecule, expanding its versatility in biological processes3. RGMA plays a critical role in axonal guidance, neuronal differentiation, and survival, primarily by interacting with the receptor neogenin. This interaction also regulates apoptosis via Akt pathway dephosphorylation. RGMA acts as a Bone Morphogenetic Protein (BMP) co-receptor, enhancing Smad-dependent signaling pathways2,3. It is expressed in the central nervous system (CNS), particularly in retinal ganglion cells, midbrain dopaminergic neurons, and the spinal cord, with roles extending from embryonic development to adult neuroplasticity1,3,4. RGMA is implicated in several biological processes, including axonal regeneration and inhibition, neuronal survival, and inflammatory responses. Pathological upregulation of RGMA has been linked to neurodegenerative disorders like multiple sclerosis (MS) and Parkinson's disease. In MS, RGMA inhibits axonal regeneration, while in Parkinson's, it contributes to dopaminergic neuron degeneration1,4,5. Research areas benefiting from RGMA immunodetection include neuroregeneration, CNS repair, and therapeutic strategies for neurodegenerative diseases4,5.

Gen-ID: 244058

UniProt: Q6PCX7

Pathways: Tube Formation