TRIM27 Antikörper (AA 200-513)

Produktnummer ABIN7118412

Dieses Anti-TRIM27-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TRIM27 in WB, IHC, ELISA, IF und IP. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TRIM27 Antikörper (AA 200-513) (ABIN7118412)

Target: TRIM27 (Tripartite Motif Containing 27 (TRIM27))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM27 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-TRIM27 Antikörper

Bindungsspezifität: AA 200-513

Verwendungszweck: TRIM27 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 200-513aa

Immunogen: tripartite motif-containing 27

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu TRIM27

Target: TRIM27 (Tripartite Motif Containing 27 (TRIM27))

Andere Bezeichnung: TRIM27

Hintergrund:

Synonyms: Zinc finger protein RFP|RING finger protein 76|Ret finger protein|Tripartite motif-containing protein 27|TRIM27|RFP|RNF76

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity, mediates the formation of 'Lys-48'-linked polyubiquitin chains, the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Molekulargewicht: 58 kDa

Gen-ID: 5987

UniProt: P14373