RFX3 Antikörper

Produktnummer ABIN7118388

Dieses Anti-RFX3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RFX3 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für RFX3 Antikörper (ABIN7118388)

Target: RFX3 (Regulatory Factor X 3 (RFX3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFX3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RFX3 Antikörper

Verwendungszweck: RFX3 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: regulatory factor X, 3(influences HLA class II expression)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RFX3

Target: RFX3 (Regulatory Factor X 3 (RFX3))

Andere Bezeichnung: RFX3

Hintergrund:

Synonyms: Transcription factor RFX3|Regulatory factor X 3|RFX3

Background: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly(DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility(DNAH11, DNAH9 and DNAH5)(By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP(polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes(PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells(PubMed:12411430).

Molekulargewicht: 70-79 kDa

Gen-ID: 5991

UniProt: P48380